← all disease traces
Congenital hypothyroidism
TSHR / TPOOMIM 218700do(free_t4 ↓)
loss-of-function of thyroid hormone synthesis/responsiveness -> low T4; loss of negative feedback raises TSH.
thyroid-stimulating hormone (thyrotropin) ↑HPO: Elevated circulating thyroid-stimulating hormone concentrationHP:0002925
comparative-statics (steady-state) net: ↑
free plasma thyroxine (free T4) ↓ →(-) anterior-pituitary thyrotropin (TSH) secretory output (rate) ↑ →(+) thyroid-stimulating hormone (thyrotropin) ↑
free plasma thyroxine (free T4) ↓ →(-) hypothalamic thyrotropin-releasing hormone concentration ↑ →(+) anterior-pituitary thyrotropin (TSH) secretory output (rate) ↑ →(+) thyroid-stimulating hormone (thyrotropin) ↑
free plasma thyroxine (free T4) ↓ →(+) free plasma triiodothyronine (free T3) ↓ →(-) anterior-pituitary thyrotropin (TSH) secretory output (rate) ↑ →(+) thyroid-stimulating hormone (thyrotropin) ↑
free plasma thyroxine (free T4) ↓ →(-) anterior-pituitary thyrotroph TSH secretion rate ↑ ↠(production +) anterior-pituitary thyrotropin (TSH) secretory output (rate) ↑ →(+) thyroid-stimulating hormone (thyrotropin) ↑
free plasma thyroxine (free T4) ↓ →(-) hypothalamic thyrotropin-releasing hormone concentration ↑ →(+) anterior-pituitary thyrotroph TSH secretion rate ↑ ↠(production +) anterior-pituitary thyrotropin (TSH) secretory output (rate) ↑ →(+) thyroid-stimulating hormone (thyrotropin) ↑
free plasma triiodothyronine (free T3) ↓
comparative-statics (steady-state) net: ↓
free plasma thyroxine (free T4) ↓ →(+) free plasma triiodothyronine (free T3) ↓
whole-body basal/resting metabolic rate (O2 consumption) ↓HPO: Decreased resting energy expenditureHP:0012340
comparative-statics (steady-state) net: ?
free plasma thyroxine (free T4) ↓ →(-) hypothalamic thyrotropin-releasing hormone concentration ↑ →(+) anterior-pituitary lactotroph prolactin secretory output (rate) ↑ →(+) plasma prolactin concentration ↑ →(-) hypothalamic gonadotropin-releasing hormone concentration / pulse drive ↓ →(+) anterior-pituitary luteinizing-hormone secretory output (rate) ↓ →(+) plasma luteinizing hormone concentration ↓ →(+) plasma 17-beta-estradiol concentration ↓ →(-) adipose (fat) tissue mass ↑ →(+) plasma leptin concentration ↑ →(+) whole-body basal/resting metabolic rate (O2 consumption) ↑
free plasma thyroxine (free T4) ↓ →(-) hypothalamic thyrotropin-releasing hormone concentration ↑ →(+) anterior-pituitary lactotroph prolactin secretory output (rate) ↑ →(+) plasma prolactin concentration ↑ →(-) hypothalamic gonadotropin-releasing hormone concentration / pulse drive ↓ →(+) anterior-pituitary luteinizing-hormone secretory output (rate) ↓ →(+) plasma luteinizing hormone concentration ↓ →(+) plasma 17-beta-estradiol concentration ↓ →(+) anterior-pituitary growth-hormone secretory output (rate) ↓ →(+) plasma growth hormone (somatotropin) concentration ↓ →(+) whole-body basal/resting metabolic rate (O2 consumption) ↓
free plasma thyroxine (free T4) ↓ →(-) hypothalamic thyrotropin-releasing hormone concentration ↑ →(+) anterior-pituitary lactotroph prolactin secretory output (rate) ↑ →(+) plasma prolactin concentration ↑ →(-) hypothalamic gonadotropin-releasing hormone concentration / pulse drive ↓ →(+) anterior-pituitary luteinizing-hormone secretory output (rate) ↓ →(+) plasma luteinizing hormone concentration ↓ →(+) plasma 17-beta-estradiol concentration ↓ →(-) adipose (fat) tissue mass ↑ →(+) plasma insulin concentration ↑ →(+) plasma testosterone concentration ↑ →(+) whole-body basal/resting metabolic rate (O2 consumption) ↑
free plasma thyroxine (free T4) ↓ →(-) hypothalamic thyrotropin-releasing hormone concentration ↑ →(+) anterior-pituitary lactotroph prolactin secretory output (rate) ↑ →(+) plasma prolactin concentration ↑ →(-) hypothalamic gonadotropin-releasing hormone concentration / pulse drive ↓ →(+) anterior-pituitary luteinizing-hormone secretory output (rate) ↓ →(+) plasma luteinizing hormone concentration ↓ →(+) plasma 17-beta-estradiol concentration ↓ →(-) adipose (fat) tissue mass ↑ →(+) adipocyte leptin secretion rate ↑ ↠(production +) plasma leptin concentration ↑ →(+) whole-body basal/resting metabolic rate (O2 consumption) ↑
free plasma thyroxine (free T4) ↓ →(-) hypothalamic thyrotropin-releasing hormone concentration ↑ →(+) anterior-pituitary lactotroph prolactin secretory output (rate) ↑ →(+) plasma prolactin concentration ↑ →(-) hypothalamic gonadotropin-releasing hormone concentration / pulse drive ↓ →(+) anterior-pituitary luteinizing-hormone secretory output (rate) ↓ →(+) plasma luteinizing hormone concentration ↓ →(+) plasma 17-beta-estradiol concentration ↓ →(+) circulating hepatic insulin-like growth factor 1 concentration ↓ →(-) anterior-pituitary growth-hormone secretory output (rate) ↑ →(+) plasma growth hormone (somatotropin) concentration ↑ →(+) whole-body basal/resting metabolic rate (O2 consumption) ↑
comparative-statics (steady-state) net: ?
free plasma thyroxine (free T4) ↓ →(-) hypothalamic thyrotropin-releasing hormone concentration ↑ →(+) anterior-pituitary lactotroph prolactin secretory output (rate) ↑ →(+) plasma prolactin concentration ↑ →(-) hypothalamic gonadotropin-releasing hormone concentration / pulse drive ↓ →(+) anterior-pituitary luteinizing-hormone secretory output (rate) ↓ →(+) plasma luteinizing hormone concentration ↓ →(+) plasma 17-beta-estradiol concentration ↓ →(+) plasma (ionised) calcium concentration ↓ →(+) myocardial contractility (intrinsic inotropic state / end-systolic elastance) ↓ →(-) right atrial pressure ↑ →(+) heart rate ↑
free plasma thyroxine (free T4) ↓ →(-) hypothalamic thyrotropin-releasing hormone concentration ↑ →(+) anterior-pituitary lactotroph prolactin secretory output (rate) ↑ →(+) plasma prolactin concentration ↑ →(-) hypothalamic gonadotropin-releasing hormone concentration / pulse drive ↓ →(+) anterior-pituitary luteinizing-hormone secretory output (rate) ↓ →(+) plasma luteinizing hormone concentration ↓ →(+) plasma 17-beta-estradiol concentration ↓ →(-) adipose (fat) tissue mass ↑ →(+) plasma insulin concentration ↑ →(-) plasma potassium concentration ↓ →(-) heart rate ↑
free plasma thyroxine (free T4) ↓ →(-) hypothalamic thyrotropin-releasing hormone concentration ↑ →(+) anterior-pituitary lactotroph prolactin secretory output (rate) ↑ →(+) plasma prolactin concentration ↑ →(-) hypothalamic gonadotropin-releasing hormone concentration / pulse drive ↓ →(+) anterior-pituitary luteinizing-hormone secretory output (rate) ↓ →(+) plasma luteinizing hormone concentration ↓ →(+) plasma progesterone concentration ↓ →(+) plasma 11-deoxycorticosterone (DOC) concentration ↓ →(+) mean arterial pressure ↓ →(-) baroreflex sympathetic outflow ↑ →(+) heart rate ↑
free plasma thyroxine (free T4) ↓ →(-) hypothalamic thyrotropin-releasing hormone concentration ↑ →(+) anterior-pituitary lactotroph prolactin secretory output (rate) ↑ →(+) plasma prolactin concentration ↑ →(-) hypothalamic gonadotropin-releasing hormone concentration / pulse drive ↓ →(+) anterior-pituitary luteinizing-hormone secretory output (rate) ↓ →(+) plasma luteinizing hormone concentration ↓ →(+) plasma testosterone concentration ↓ →(-) adipose (fat) tissue mass ↑ →(+) plasma insulin concentration ↑ →(-) plasma potassium concentration ↓ →(-) heart rate ↑
free plasma thyroxine (free T4) ↓ →(-) hypothalamic thyrotropin-releasing hormone concentration ↑ →(+) anterior-pituitary lactotroph prolactin secretory output (rate) ↑ →(+) plasma prolactin concentration ↑ →(-) hypothalamic gonadotropin-releasing hormone concentration / pulse drive ↓ →(+) anterior-pituitary luteinizing-hormone secretory output (rate) ↓ →(+) plasma luteinizing hormone concentration ↓ →(+) plasma 17-beta-estradiol concentration ↓ →(-) adipose (fat) tissue mass ↑ →(+) plasma insulin concentration ↑ →(+) net cellular (transcellular) potassium uptake rate ↑ →(-) plasma potassium concentration ↓ →(-) heart rate ↑
plasma LDL-cholesterol concentration ↑HPO: HypercholesterolemiaHP:0003124
comparative-statics (steady-state) net: ?
free plasma thyroxine (free T4) ↓ →(-) hypothalamic thyrotropin-releasing hormone concentration ↑ →(+) anterior-pituitary lactotroph prolactin secretory output (rate) ↑ →(+) plasma prolactin concentration ↑ →(-) hypothalamic gonadotropin-releasing hormone concentration / pulse drive ↓ →(+) anterior-pituitary luteinizing-hormone secretory output (rate) ↓ →(+) plasma luteinizing hormone concentration ↓ →(+) plasma 17-beta-estradiol concentration ↓ →(-) plasma LDL-cholesterol concentration ↑
free plasma thyroxine (free T4) ↓ →(-) hypothalamic thyrotropin-releasing hormone concentration ↑ →(+) anterior-pituitary lactotroph prolactin secretory output (rate) ↑ →(+) plasma prolactin concentration ↑ →(-) hypothalamic gonadotropin-releasing hormone concentration / pulse drive ↓ →(+) anterior-pituitary luteinizing-hormone secretory output (rate) ↓ →(+) plasma luteinizing hormone concentration ↓ →(+) plasma testosterone concentration ↓ →(+) plasma 17-beta-estradiol concentration ↓ →(-) plasma LDL-cholesterol concentration ↑
free plasma thyroxine (free T4) ↓ →(-) hypothalamic thyrotropin-releasing hormone concentration ↑ →(+) anterior-pituitary lactotroph prolactin secretory output (rate) ↑ →(+) plasma prolactin concentration ↑ →(-) hypothalamic gonadotropin-releasing hormone concentration / pulse drive ↓ →(+) anterior-pituitary luteinizing-hormone secretory output (rate) ↓ →(+) plasma luteinizing hormone concentration ↓ →(+) plasma 17-beta-estradiol concentration ↓ →(+) anterior-pituitary growth-hormone secretory output (rate) ↓ →(+) plasma growth hormone (somatotropin) concentration ↓ →(-) plasma LDL-cholesterol concentration ↑
free plasma thyroxine (free T4) ↓ →(-) hypothalamic thyrotropin-releasing hormone concentration ↑ →(+) anterior-pituitary lactotroph prolactin secretory output (rate) ↑ →(+) plasma prolactin concentration ↑ →(-) hypothalamic gonadotropin-releasing hormone concentration / pulse drive ↓ →(+) anterior-pituitary luteinizing-hormone secretory output (rate) ↓ →(+) plasma luteinizing hormone concentration ↓ →(+) plasma 17-beta-estradiol concentration ↓ →(-) adipose (fat) tissue mass ↑ →(+) plasma insulin concentration ↑ →(?) hepatic VLDL secretion rate ? →(+) plasma LDL-cholesterol concentration ?
free plasma thyroxine (free T4) ↓ →(-) hypothalamic thyrotropin-releasing hormone concentration ↑ →(+) anterior-pituitary lactotroph prolactin secretory output (rate) ↑ →(+) plasma prolactin concentration ↑ →(-) hypothalamic gonadotropin-releasing hormone concentration / pulse drive ↓ →(+) anterior-pituitary luteinizing-hormone secretory output (rate) ↓ →(+) plasma luteinizing hormone concentration ↓ →(+) plasma 17-beta-estradiol concentration ↓ →(-) adipose (fat) tissue mass ↑ →(+) plasma insulin concentration ↑ →(+) plasma testosterone concentration ↑ →(+) plasma LDL-cholesterol concentration ↑
↑ increased ↓ decreased ? magnitude-dependent (SCC). →(+) positive edge, →(−) negative, ▷ cross-scale constitutive lift. Endophenotypes are real HPO directional terms. Draft for domain review.