← all disease traces
Central diabetes insipidus
AVPOMIM 125700do(adh ↓)
deficient arginine-vasopressin (ADH) secretion -> loss of renal free-water reabsorption.
plasma osmolality ↑HPO: High serum osmolalityHP:6000681
comparative-statics (steady-state) net: ?
antidiuretic hormone (vasopressin) concentration ↓ →(+) renal tubular sodium and water reabsorption ↓ →(+) blood volume ↓ →(+) atrial natriuretic peptide concentration ↓ →(-) plasma renin activity ↑ →(+) plasma angiotensin II concentration ↑ →(+) water intake (drinking / thirst-driven ingestion) ↑ →(-) plasma osmolality ↓
antidiuretic hormone (vasopressin) concentration ↓ →(+) renal tubular sodium and water reabsorption ↓ →(+) blood volume ↓ →(+) atrial natriuretic peptide concentration ↓ →(-) plasma renin activity ↑ →(+) plasma angiotensin II concentration ↑ →(+) water intake (drinking / thirst-driven ingestion) ↑ →(-) plasma sodium concentration ↓ →(+) plasma osmolality ↓
antidiuretic hormone (vasopressin) concentration ↓ →(+) renal tubular sodium and water reabsorption ↓ →(+) blood volume ↓ →(+) atrial natriuretic peptide concentration ↓ →(-) total peripheral resistance ↑ =(identity +) mean arterial pressure ↑ →(-) baroreflex sympathetic outflow ↓ →(+) plasma renin activity ↓ →(+) plasma angiotensin II concentration ↓ →(+) water intake (drinking / thirst-driven ingestion) ↓ →(-) plasma osmolality ↑
antidiuretic hormone (vasopressin) concentration ↓ →(+) renal tubular sodium and water reabsorption ↓ →(+) blood volume ↓ →(+) atrial natriuretic peptide concentration ↓ →(-) total peripheral resistance ↑ =(identity +) mean arterial pressure ↑ →(+) renal perfusion pressure ↑ →(-) plasma renin activity ↓ →(+) plasma angiotensin II concentration ↓ →(+) water intake (drinking / thirst-driven ingestion) ↓ →(-) plasma osmolality ↑
antidiuretic hormone (vasopressin) concentration ↓ →(+) renal tubular sodium and water reabsorption ↓ →(+) blood volume ↓ →(+) atrial natriuretic peptide concentration ↓ →(-) total peripheral resistance ↑ →(-) cardiac output ↓ =(identity +) mean arterial pressure ↓ →(-) baroreflex sympathetic outflow ↑ →(+) plasma renin activity ↑ →(+) plasma angiotensin II concentration ↑ →(+) water intake (drinking / thirst-driven ingestion) ↑ →(-) plasma osmolality ↓
plasma sodium concentration ↑HPO: HypernatremiaHP:0003228
comparative-statics (steady-state) net: ?
antidiuretic hormone (vasopressin) concentration ↓ →(+) renal tubular sodium and water reabsorption ↓ →(+) blood volume ↓ →(+) atrial natriuretic peptide concentration ↓ →(-) plasma renin activity ↑ →(+) plasma angiotensin II concentration ↑ →(+) water intake (drinking / thirst-driven ingestion) ↑ →(-) plasma sodium concentration ↓
antidiuretic hormone (vasopressin) concentration ↓ →(+) renal tubular sodium and water reabsorption ↓ →(+) blood volume ↓ →(+) atrial natriuretic peptide concentration ↓ →(-) total peripheral resistance ↑ =(identity +) mean arterial pressure ↑ →(-) baroreflex sympathetic outflow ↓ →(+) plasma renin activity ↓ →(+) plasma angiotensin II concentration ↓ →(+) water intake (drinking / thirst-driven ingestion) ↓ →(-) plasma sodium concentration ↑
antidiuretic hormone (vasopressin) concentration ↓ →(+) renal tubular sodium and water reabsorption ↓ →(+) blood volume ↓ →(+) atrial natriuretic peptide concentration ↓ →(-) total peripheral resistance ↑ =(identity +) mean arterial pressure ↑ →(+) renal perfusion pressure ↑ →(-) plasma renin activity ↓ →(+) plasma angiotensin II concentration ↓ →(+) water intake (drinking / thirst-driven ingestion) ↓ →(-) plasma sodium concentration ↑
antidiuretic hormone (vasopressin) concentration ↓ →(+) renal tubular sodium and water reabsorption ↓ →(+) blood volume ↓ →(+) venous return / mean systemic filling pressure ↓ →(+) cardiac output ↓ =(identity +) mean arterial pressure ↓ →(-) baroreflex sympathetic outflow ↑ →(+) plasma renin activity ↑ →(+) plasma angiotensin II concentration ↑ →(+) water intake (drinking / thirst-driven ingestion) ↑ →(-) plasma sodium concentration ↓
antidiuretic hormone (vasopressin) concentration ↓ →(+) renal tubular sodium and water reabsorption ↓ →(+) blood volume ↓ →(+) venous return / mean systemic filling pressure ↓ →(+) cardiac output ↓ =(identity +) mean arterial pressure ↓ →(+) renal perfusion pressure ↓ →(-) plasma renin activity ↑ →(+) plasma angiotensin II concentration ↑ →(+) water intake (drinking / thirst-driven ingestion) ↑ →(-) plasma sodium concentration ↓
↑ increased ↓ decreased ? magnitude-dependent (SCC). →(+) positive edge, →(−) negative, ▷ cross-scale constitutive lift. Endophenotypes are real HPO directional terms. Draft for domain review.